DNA Analysis & Genetic Genealogy
How genetic evidence revolutionized criminal investigation
How DNA Evidence Works
DNA (deoxyribonucleic acid) is the genetic blueprint found in nearly every cell of the human body. In forensic science, analysts examine specific regions called STRs (Short Tandem Repeats)—sections where nucleotide sequences repeat. The number of repeats varies between individuals, creating a unique genetic "fingerprint."
When biological evidence is collected from a crime scene—blood, semen, skin cells, hair with follicles—technicians extract and amplify the DNA using PCR (Polymerase Chain Reaction). The resulting profile is compared against known samples or database entries.
CODIS: The DNA Database
The Combined DNA Index System (CODIS) is the FBI's database containing DNA profiles from convicted offenders, arrestees, and forensic evidence from unsolved cases. When investigators enter a crime scene profile, CODIS searches for matches against millions of records. A "hit" can link crimes to each other or identify suspects.
However, CODIS only works if the perpetrator's DNA is already in the system. This limitation led to the development of genetic genealogy.
Genetic Genealogy Revolution
In 2018, investigators identified the Golden State Killer using a technique called investigative genetic genealogy. Rather than searching law enforcement databases, they uploaded crime scene DNA to public genealogy sites like GEDmatch. By finding distant relatives and building family trees, they narrowed suspects to Joseph DeAngelo.
This technique has since solved hundreds of cold cases, including the Long Island Serial Killer case. It works because even partial matches to third or fourth cousins can, through genealogical research, lead to specific suspects.
Limitations & Controversies
DNA evidence isn't infallible. Contamination can occur during collection or processing. Touch DNA (from skin cells) can transfer innocently—you can leave DNA on objects you never touched if it transferred from your handshake. Identical twins share DNA profiles.
Genetic genealogy raises privacy concerns: people who submitted DNA for ancestry research didn't consent to criminal investigations. Some databases now require explicit opt-in for law enforcement searches.
Case Example
The Golden State Killer case demonstrated genetic genealogy's power. After 40 years, DNA from 1970s crime scenes matched distant relatives in genealogy databases, leading to Joseph DeAngelo's 2018 arrest.